INDUCING VULNERABILITY TO INHA INHIBITION RESTORES ISONIAZID SUSCEPTIBILITY IN DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis

ABSTRACT Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH).INH resistance is predominantly caused by mutations that decrease the activity of the bacterial enzyme KatG, which mediates the conversion of the pro-drug INH to its active form

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Development of a Genome-Scale Metabolic Model of Clostridium thermocellum and Its Applications for Integration of Multi-Omics Datasets and Computational Strain Design

Solving environmental and social challenges such as climate change requires a shift from our current non-renewable manufacturing model to a sustainable bioeconomy.To lower carbon emissions in the production of fuels and chemicals, plant biomass arrow add on feedstocks can replace petroleum using microorganisms as biocatalysts.The anaerobic thermoph

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An Aircraft Detection Framework Based on Reinforcement Learning and Convolutional Neural Networks in Remote Sensing Images

Aircraft detection has attracted increasing attention in the field of remote sensing image analysis.Complex background, illumination change and variations Polo of aircraft kind and size in remote sensing images make the task challenging.In our work, we propose an effective aircraft detection framework based on reinforcement learning and a convoluti

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